The Global Fund’s Eighth Replenishment: How Canada Can Help Protect Decades of Progress
Canada has long supported global efforts to end tuberculosis (TB), HIV, and malaria — including through key engagement with the Global Fund. Today, we face a pivotal moment of choice: to protect gains or risk losing them.
The Global Fund’s 2025 Results Report shows that after decades of global efforts:
TB treatment reached 75% coverage in Global Fund–supported countries in 2023 – the highest level ever achieved – up from 45% in 2010
Since its inception, the Global Fund partnership has helped reduce the combined death rate from HIV, TB, and malaria by 63%
Investments in health systems have improved lab capacity, trained health workers, and expanded access to care, allowing countries to respond faster to outbreaks.
These are extraordinary results, but they are now under threat. New crises, funding gaps, and competing global priorities risk reversing decades of progress.
The Eighth Replenishment
The investment case is clear. With US$18 billion in new funding, the Global Fund could, between 2027 and 2029:
Save 23 million more lives
Prevent 400 million infections
Further reduce the death rate by 64%
Deliver over US$300 billion in health and economic gains
70 Million Reasons to Invest in the Global Fund
The Global Fund has already saved 70 million lives. But the story isn’t complete. Hundreds of millions more stand to benefit if the commitment is renewed and scaled.
Every dollar counts. For every US$1 invested in the Global Fund, US$19 in economic returns are generated through better health, increased productivity, and reduced healthcare costs.
The Global Fund is the largest multilateral provider of health system strengthening, investing US$2 billion annually to train health workers, strengthen labs, and stop outbreaks before they spread.
From reducing HIV incidence among adolescent girls by 69% to removing barriers rooted in stigma and discrimination, the Global Fund ensures the most vulnerable are not left behind.
With 71% of funding directed to climate-vulnerable countries, Global Fund programs strengthen health systems to withstand climate shocks and keep treatment and care on track.
Direct Benefits to Canadians
By strengthening health systems abroad, the Global Fund directly contributes to the health of Canadians by reducing the risk of infectious diseases in Canada and countries where Canadians travel. This is particularly relevant to Canada’s own TB elimination goals, as TB cases among migrant populations represent the majority of new TB cases in Canada.
Why Canada’s Leadership Matters
Canada has been a consistent supporter of the Global Fund, recognizing its impact in saving lives and advancing gender equity, human rights, and health system resilience. In 2022, Canada made its largest-ever pledge: CAD $1.21 billion. Today, as global threats worsen and inequalities deepen, we must build on that leadership.
A bold pledge to the Global Fund can create a multiplier effect:
We can signal to the world that we will not turn away from the unfinished fight against TB, HIV, and malaria, prompting countries to invest domestically in their health systems
We reaffirm the importance of resilient health systems in all countries in times of global threats like climate change and antimicrobial resistance (AMR)
We can extend our global health leadership, reinforcing Canada’s commitment to equity, human rights, and health security.
We can directly advance Canada’s national health objective including achieving TB elimination which requires a reduction in the global burden of disease.
In a time where many G7 countries are stepping back from aid, Canada takes a bold step to help reform what equitable collaboration between North and South can look like. Together, we can help ensure that decades of progress are not lost, and that a healthier, more equitable world is within reach.